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This derivative could be acetylated, hydroxylated and glucuronidated. Cytochrome P-450 together with CYP3A, may possibly Perform a crucial position in clonazepam reduction and oxidation. The elimination half-life of clonazepam is usually thirty to 40 hrs. Clonazepam pharmacokinetics are dose-unbiased all over the dosing variety. There isn't any evi